个人简介

南昌大学生物医学创新研究院/南昌大学第一附属医院烧伤科(江西省烧伤研究所)双聘研究员，独立PI，博士生导师。以第一作者在Nature、Int J Mol Sci、Cell Physiol Biochem等国内外期刊发表论文5篇，以共同作者Nature、Nature Immunology、Nature Communications、J Invest Dermatol、Matrix Biol等杂志发表论文13篇（H-index：11）；获两项发明专利。欧洲组织修复学会和欧洲呼吸学会会员； Bioengineering，IJMS, CIMB, Medicina, Dermato, Cell and developmental biology, Journal of Ovarian Research, European Journal of Medical Research, Reproductive Biology, BMC Pregnancy and Childbirth, BMC Molecular and Cell Biology等杂志审稿人。

研究方向

主要从事筋膜和细胞外基质动员在多器官系统的组织修复与再生、疤痕形成和纤维化中的作用和机制研究。主要使用小鼠皮肤损伤模型、体外3D培养以及活体成像技术、单细胞转录组学和遗传谱系追踪、消融和基因删除模型，探究筋膜在伤口无疤痕愈合、衰老和慢性不愈合伤口、器官粘连和纤维化、人工卵巢构建中的作用。结合大规模药筛实验为临床上器官纤维化、慢性不愈合伤口、增生性瘢痕、瘢痕疙瘩以及女性不孕不育的治疗打开新大门。

代表性论文

1. Correa-Gallegos D#, Ye H#, Dasgupta B#, Sardogan A, Kadri S, Kandi R, Dai R, Lin Y, Kopplin R, Shenai Disha S, Wannemacher J, Ichijo R, Jiang D, Strunz M, Ansari M, Angelidis I, Schiller H, Voltz T, Hans-Günther M, Rinkevich Y*, CD201+ fascia progenitors choreograph injury repair. Nature, 2023,623(7988):792-802.

2. Ye H, Rinkevich Y*. Fascia Layer-A Novel Target for the Application of Biomaterials in Skin Wound Healing. Int J Mol Sci, 2023,24(3):2936.

3. Correa-Gallegos D#, Jiang D#, Christ S, Ramesh P, Ye H, Wannemacher J, Kalgudde Gopal S, Yu Q, Aichler M, Walch A, Mirastschijski U, Volz T, Rinkevich Y*. Patch repair of deep wounds by mobilized fascia. Nature. 2019,576(7786):287-292.

4. Fischer A#, Wannemacher J#, Christ S#, Koopmans T, Kadri S, Zhao J, Gouda M, Ye H, Mück-Häusl M, Krenn PW, Machens HG, Fässler R, Neumann PA, Hauck SM, Rinkevich Y*. Neutrophils direct preexisting matrix to initiate repair in damaged tissues. Nat Immunol, 2022,23(4):518-531.

5. Jiang D#, Christ S#, Correa-Gallegos D#, Ramesh P#, Kalgudde Gopal S, Wannemacher J, MayrCH, Lupperger V, Yu Q, Ye H, Mück-Häusl M, Rajendran V, Wan L, Liu J, Mirastschijski U, Volz T, Marr C, Schiller HB, Rinkevich Y*. Injury triggers fascia fibroblast collective cell migration to drive scar formation through N-cadherin. Nat Commun, 2020,11(1):5653.

6. Ye H, Zheng T, Li W, Li X, Fu X, Huang Y, Hu C, Li J, Huang J, Liu Z, Zheng L, Zheng Y. Ovarian Stem Cell Nests in Reproduction and Ovarian Aging. Cell Physiol Biochem, 2017,43(5):1917-1925.

7. Ye H, Li X, Zheng T, Hu C, Pan Z, Huang J, Li J, Li W, Zheng Y. The Hippo Signaling Pathway Regulates Ovarian Function via the Proliferation of Ovarian Germline Stem Cells. Cell Physiol Biochem,2017,41(3):1051-1062.

8. Ye H, Li X, Zheng T, Liang X, Li J, Huang J, Pan Z, Zheng Y. The effect of the immu ne system on ovarian function and features of ovarian germline stem cells. Springerplus, 2016,7;5(1):990.

主持项目

1.南昌大学高层次人才启动经费，课题负责人：叶海峰，2024-2030（300万）