个人简介

雷洋，南昌大学生物医学创新研究院/南昌大学第一附属医院心内科双聘研究员，独立PI，博士生导师。曾任四川大学国家生物医学材料工程技术研究中心副研究员。美国哈佛大学医学院博士后，美国克莱姆森大学博士，国家级人才。以第一作者或通讯作者在Journal of Controlled Release, Acta Biomaterialia等杂志发表学术论文39篇。申请中国发明专利56项，授权35项。团队46项（其中含本人作为共同发明人专利19项，第一发明人专利8项）专利关键技术已转让至国内心脏瓣膜领域处于领军地位的上市企业，转让金额1380万元。作为负责人主持国家重点研发计划课题1项、国家自然科学基金面上项目1项、国家自然科学基金青年科学基金1项、横向技术开发1项，获批科研经费超800万元。获教育部技术发明奖一等奖、中韩生物材料学会年会青年科学家奖、第十七届“挑战杯”全国大学生课外学术科技作品竞赛全国特等奖。担任Journal of Leather Science and Engineering杂志青年编委。

研究方向

1.心血管生物医用材料及器械，包括人工生物心脏瓣膜瓣叶材料

2.胶原蛋白医用材料

3.医用粘合剂

4.眼科医用材料

代表性论文

1. Kailei Ding, Cheng Zheng, Xueyu Huang, Li Yang, Yang Lei*, Yunbing Wang*. A bioprosthetic heart valve material prepared by copolymerization of 2-Amino-4-pentanoic acid modified pericardium and N, N-Dimethylacrylamide. Composites Part B: Engineering. 2022, 243, 110120.

2. Cheng Zheng, Kailei Ding, Xueyu Huang, Li Yang, Yang Lei* and Yunbing Wang. A bioprosthetic heart valve prepared by copolymerization of 2-isocyanatoethyl methacrylate modified pericardium and functional monomer. Composites Part B: Engineering. 2022, 238, 109922.

3. Shumang Zhang, Cheng Zheng, Meiling Li, Kailei Ding, Xueyu Huang, Xuyue Liang, Yang Lei*, Qing Jiang*, Yunbing Wang*. Sodium lignosulfonate cross-linked bioprosthetic heart valve materials for enhanced cytocompatibility, improved hemocompatibility, and reduced calcification. Composites Part B: Engineering. 2022, 234, 109669.

4. Yang Lei, Nasim Nosoudi, and Naren Vyavahare*. Targeted chelation therapy with EDTA-loaded albumin nanoparticles regresses arterial calcification without causing systemic side effects. Journal of Controlled Release. 2014, 196:79-86.

5. Gaoyang Guo, Linhe Jin, Binggang Wu, Haiyang He, Fan Yang, Liangpeng Xu, Yang Lei*, Yunbing Wang*. A method for simultaneously crosslinking and functionalizing extracellular matrix-based biomaterials as bioprosthetic heart valves with enhanced endothelialization and reduced inflammation. Acta Biomaterialia. 2021, 119, 89-100.

6. Gaoyang Guo, Linhe Jin, Wanyu jin, Liang Chen, Yang Lei*, Yunbing Wang*. Radical polymerization-crosslinking method for improving extracellular matrix stability in bioprosthetic heart valves with reduced potential for calcification and inflammatory response. Acta Biomaterialia. 2018, 82:44-55.

7. Li Yang, Shuang Xie, Kailei Ding, Yang Lei*, and Yunbing Wang. The study of dry biological valve crosslinked with a combination of carbodiimide and polyphenol. Regenerative Biomaterials. 2021, 8(1): rbaa049. DOI: 10.1093/rb/rbaa049.

8. Yang Lei#, Xiaorong Lan#, Zhoukun He*, Anlin Yin, Wanyu Jin, Qinsheng Hu, Yunbing Wang*. Multifarious anti-biofouling bioprosthetic heart valve materials with the formation of interpenetrating polymer network structures. Materials & Design. 2021, 206, 109803.

9. Xiaorong Lan#, Yang Lei#, Zhoukun He*, Anlin Yin, Linhua Li, Zhonglan Tang, Meiling Li, Yunbing Wang*. A transparent hydrophilic anti-biofouling coating for intraocular lens materials prepared by "bridging" of the intermediate adhesive layer. Journal of Materials Chemistry B. 2021, 9, 3696-3704.

10. Binggang Wu#, Cheng Zheng#, Kailei Ding, Xueyu Huang, Meiling Li, Shumang Zhang, Yang Lei*, Yingqiang Guo, Yunbing Wang*. Cross-Linking Porcine Pericardium by 3,4-Dihydroxybenzaldehyde: A Novel Method to Improve the Biocompatibility of Bioprosthetic Valve. Biomacromolecules. 2021, 22(2):823-836.

主持项目

1. 南昌大学高层次人才启动经费，项目负责人：雷洋，2024-2030；

2. 国家自然科学基金面上项目，亲/疏水单体碳碳双键聚合交联生物瓣膜瓣叶材料结构性能关系研究，项目负责人：雷洋，2023至 2026；

3. 国家重点研发计划，新型预装式介入心脏瓣膜系统的研制与开发，课题负责人：雷洋，2017至2021；

4. 国家自然科学基金青年科学基金，弹性蛋白及糖胺聚糖稳定交联处理提高生物心脏瓣膜抗钙化性能研究，项目负责人：雷洋，2018至2020；

5. 横向技术开发，高分子心瓣的评估以及开发，项目负责人：雷洋，2019至2020。