个人简介

教育经历：

(1) 1999-9至2004-3, 中科院生化细胞所, 生化分子生物学, 获博士学位

(2) 1996-9至1999-7, 中国药科大学, 分子药理学, 获硕士学位

(3) 1992-9至1996-7, 山东师范大学, 生物学, 获学士学位

工作经历：

(1) 2011-1至现在, 南昌大学, 生物医学创新研究院, 研究员

(2) 2004-7至2010-12, University of Pennsylvania School of Medicine, 博士后

研究方向

神经环路发育与疾病，目前集中于发育相关神经精神疾病如孤独症，从分子、细胞和神经环路水平上解析其致病机制，为神经发育疾病的诊断和防治提供实验依据。

代表性论文

1. Zhu J, Wang H, Chen YR, Yan LY, Han YY, Liu LY, Cao Y, Liu ZZ, Xu HA*. The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neurosci Bull. 2020 Sep;36(9):1023-1034.

2. Long X, Wang S, Luo Z, Zhang, X, Xu HA* . Comparison of three administration modes of establishing a zebrafish seizure model induced by NMDA. World Journal of Psychiatry. 2020 July 19; 10(7): 150-161.

3. Ying Chen, Hantsing Wang, Fang Wang, Chen Chen, Peng Zhang, Dandan Song, Tao Luo, Hong Xu*, Xuhui Zeng*. Sperm motility modulated by Trpv1 regulates zebrafish fertilization. Theriogenology. 2020 Jul 15;151:41-51.

4. Liu ZZ, Guo J, Lu Y, Liu W, Fu X, Yao T, Zhou Y, Xu HA*. Sema3E is required for migration of cranial neural crest cells in zebrafish: Implications for the pathogenesis of CHARGE syndrome. Int J Exp Pathol. 2019 Aug;100(4):234-243.

5. Luo ZW, Wang HT, Wang N, Sheng WW, Jin M, Lu Y, Bai YJ, Zou SQ, Pang YL, Xu HA*, Zhang X* . Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA. Int J Ophthalmol.2019Aug 18; 12 (8):1250-1261.

6. Zhu L, Chen L, Yan L, Perkins BD, Li S, Li B*, Xu HA*, Li XJ*. Mutant Ahi1 Affects Retinal Axon Projection in Zebrafish via Toxic Gain of Function. Front Cell Neurosci. 2019 Mar 21;13:81.

7. Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong Xu*. CRMP2 and CRMP4 are differentially required for axon guidance and growth in zebrafish retinal neurons. Neural Plasticity 2018 Jun 21; 2018:8791304.

8. Zhi-Zhi Liu, Zi-Long Wang, Tae-Ik Choi, Wen-Ting Huang, Han-Tsing Wang, Ying-Ying Han, Lou-Yin Zhu, Hyun-Taek Kim, Jung-Hwa Choi, Jin-Soo Lee, Hyung-Goo Kim, Jian Zhao, Yue Chen, Zhuo Lu, Xiao-Li Tian, Bing-Xing Pan, Bao-Ming Li, Cheol-Hee Kim*, Hong Xu*. Chd7 is critical for early T-cell development and thymus organogenesis in zebrafish. Am J Pathol. 2018 Apr;188(4):1043-1058.

9. Weiwei Sheng, Ye Lu, Feng Mei, Ning Wang, Zhi-Zhi Liu, Ying-Ying Han, Han-Tsing Wang, Suqi Zou, Hong Xu*, and Xu Zhang*. Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4542-4551.

10. Dell AL, Fried-Cassorla E, Xu H* and Raper JA* .cAMP-Induced Expression of Neuropilin1 Promotes Retinal Axon Crossing in the Zebrafish Optic Chiasm. J Neurosci. 2013 33(27):11076-88 (Highlighted as This Week in The Journal (TWIJ) article) (#Corresponding author)

主持项目

1. 国家自然科学基金地区项目，孤独症基因CHD8在肠神经系统发育微环境中的作用和机制，批准号82260279，起止时间2023.1-2026.12

2. 江西省科技厅，江西省主要学科学术和技术带头人培养计划领军人才，批准号20213BCJ22057，起止时间2022.1-2024.12

3. 国家自然科学基金地区项目，孤独症高风险基因chd8在肠-免疫-脑中的作用和机制，批准号31960169，起止时间2020.1-2023.12

4. 江西省自然科学基金重点项目，表观遗传因子CHD8调节肠发育的分子细胞机制及从肠到脑的途径初探，批准号20202ACB206002，起止时间2020.1-2022.12

5. 国家自然科学基金地区项目，自闭症高风险基因Chd8在神经发生中的时序性调控作用和机制研究，批准号81760216，起止时间2018.1-2021.12

6. 江西省科技厅，江西省青年科学家（杰出青年），批准号20122BCB23007，起止时间2013.01-2015.12

7. 国家自然科学基金地区项目，Sema3E在CHARGE综合症中的作用及机制研究，批准号81160144，起止时间2012.01-2015.12

8. 国家自然科学基金面上项目，CRMP蛋白家族在体内中枢神经轴突生长和导向中的作用及机制研究，批准号31171044，起止时间2012.01-2015.12