个人简介

南昌大学、第一附属医院双聘教授

南昌大学“类器官研究院”执行院长

国家级人才

国家重点研发计划“干细胞及转化研究”首席科学家（青年）

研究方向

研究成体干细胞命运决定机制，发展类器官培育新策略。以第一/通讯作者身份于国际权威期刊Cell Research、Nature Communications、Advanced Science、Protein & Cell、Developmental Cell等发表系列性研究论文，为再生生物学和类器官技术发展提供重要基础。代表性研究成果获Nature News专访报道、Nature官网主页高亮，获国际权威综述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度评价。

代表性论文

Chen J, Zhang J, Yang L and Zhao B*. (2023) Facile suspension culture protocol of the liver biliary organoids. Bio-Design and Manufacturing, 6:74–81. (*corresponding author)

2. Chen Z, Chen C, Xiao L, Tu R, Yu M, Wang D, Kang W, Han M, Huang H, Liu H, Zhao B* and Qing G*. (2023) HILPS, a novel long non-coding RNA essential for global oxygen sensing in human. Science Advances (综合1区Top), 24;9(47):eadi1867.

3. Liang J, Wei J, Cao J, Qian J, Gao R, Li X, Wang D, Gu Y, Dong L, Yu J, Zhao B* and Wang X*. (2023) In-organoid single-cell CRISPR screening reveals determinants of hepatocyte differentiation and maturation. Genome Biology (生物1区Top), 24:251.

4. Luo Z, Wang B, Luo F, Guo Y, Jiang N, Wei J, Wang X, Tseng Y, Chen J, Zhao B* and Liu J*. (2023) Establishment of a large-scale patient-derived high-risk colorectal adenoma organoid biobank for high-throughput and high-content drug screening. BMC Medicine (医学1区Top), 21:336.

5. Wang W, Yang J, Kang P, Bai J, Feng X, Huang L, Zhang Y, Wu Y, Tang B, Wang H, Jiang J, Li M, Zhao B* and Yang X. (2023) Direct infection of SARS-CoV-2 in human iPSC-derived 3D cardiac organoids recapitulates COVID-19 myocarditis. Virologica Sinica, 38:971-974.

6. Xu Y, Hu J, Lv Q, Shi C, Qiu M, Xie L, Liu W, Yang B, Shan W, Cheng Y, Zhao B* and Chen X*. (2023) Endometrium-derived mesenchymal stem cells suppress progression of endometrial cancer via the DKK1-Wnt/β-catenin signaling pathway. Stem Cell Research & Therapy, 14:159.

7. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J, Xu S and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (综合1区Top), 9:2202505.

8. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X, Wang X and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (综合1区Top), 9:2105568.

9. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1区Top), 13:683-688.

10. Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B* and Chen X*. (2022) Single-cell transcriptomic atlas highlights origin and pathological process of human endometrioid endometrial carcinoma.

Nature Communications (综合1区Top), 13:6300.

11. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1区Top), 57:901–913. (Cover Story)

12. Meng F, Shen C, Yang L, Ni C, Huang J, Lin K, Cao Z, Xu S, Cui W, Wang X, Zhou B, Xiong C, Wang J and Zhao B*. (2022) Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regeneration (高起点期刊-卓越研究论文), 11:39.

13. Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H*, Zhao B* and Lin X*. (2022) Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry, 298:102490.

14. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (医学1区Top), 14:873-886. (Cover Story and 2021 Editor’s Choice)

15. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (医学1区Top), 34:3348-3358.

16. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J, Zhang R and Lin X. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1区Top), 11:771-775. (Highlighted by Nature)

17. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12: 618-629.

Review Articles:

18. Li Y, Gao X, Ni C, Zhao B* and Cheng X*. (2023) The application of patient-derived organoid in the research of lung cancer. Cellular Oncology (医学1区Top), 46:503–519.

19. Wei J, Zhang W and Zhao B*. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration, 12:17.

2. Liang J, Li X, Dong Y and Zhao B*. (2022) Modeling human organ development and diseases with fetal tissue-derived organoids. Cell Transplantation, 31:1–15.

26. Lv T, Meng F, Yu M, Huang H, Lin X and Zhao B*. (2021) Defense of COVID‐19 by human organoids. Phenomics,1:113–128.

主持项目

1. 科技部国家重点研发计划，项目名称：染色质重构在肝脏细胞命运决定中的作用及其机制，课题负责人：赵冰，2018-2022（547万）

2. 国家自然科学基金优秀青年基金项目，项目名称：信号转导与成体干细胞命运决定，课题负责人：赵冰，2021-2023（120万）

3. 国家自然科学基金面上项目，项目名称：Znhit1基因在Lgr5小肠干细胞命运决定中的作用及其机制，课题负责人：赵冰，2018-2021（60万）

4. 国家自然科学基金面上项目，项目名称：Emc3在肠上皮稳态维持中的作用及其机制，课题负责人：赵冰，2020-2023（57万）

5. 上海市科委基础研究特区计划，项目名称：内胚层类器官构建及其形成机制研究，课题负责人：赵冰，2021-2026（400万）

6. 上海市科委基础研究特区计划，项目名称：内胚层类器官构建及其形成机制研究，课题负责人：赵冰，2021-2026（400万）

7. 云南省科技厅生物医药重大专项，项目名称：肺癌类器官平台建设及靶向、免疫新药临床前研究，课题负责人：赵冰，2023-2026（1960万）

8. 江西省科技厅重点研发计划，项目名称：胃肠道肿瘤类器官构建及微环境研究，课题负责人：赵冰，2024-2026（120万）

9. 山东省自然科学基金生物医药联合基金，项目名称：基于类器官自动化平台的恶性肿瘤高通量药物基因组学研究，课题负责人：赵冰，2024-2026（60万）

科研获奖及专利

赣鄱俊才·高校领军人才 江西省委组织部 2023

复星医药奖教金（一等） 复旦大学 2020 2021 2022

“东方学者”特聘教授 上海市教委 2019

上海市青年拔尖人才 上海市委组织部、人社局 2018

上海市青年科技启明星（A类） 上海市科委 2018

生命科学学院院长奖 复旦大学 2018

AMGEN Postdoctoral Award AMGEN 2015

北京市优博 北京市教委 2013