个人简介

中国科学院遗传与发育生物学研究所生物信息学博士，获赣鄱俊才青年人才计划及江西省杰出青年基金支持，在国际期刊上共发表SCI论文26篇，三篇论文被选为杂志封面论文，两篇论文被Science News等多家知名媒体专题报道，全部文章累计被引用2200余次，H指数16，第一作者论文单篇最高引用次数360余次，代表性研究成果受邀在国际干细胞协会年会（ISSCR）上做口头学术报告。

研究方向

长期致力于非编码RNA功能研究，发现驱动多能干细胞全能性命运转变、合子基因组激活及癌症发生发展的关键非编码RNA，解析其调控的分子机制，并进行转化应用，具体如下：

研究方向一：整合多层面组学数据，开发非编码RNA功能智能预测算法及数据库

研究方向二：鉴定调控多能干细胞全能性命运转变及合子基因组激活的关键非编码RNA，探究其作用的分子机制

研究方向三：鉴定驱动恶性肿瘤发生发展的关键非编码RNA，开展基于关键非编码RNA的新药研发

代表性论文

1. Hua Yu#*, Jing Zhao#, Yuxuan Shen, Qiao Lu, Yuheng Liu, Guanglei Xie, Shuhui Chang, Tingying Ge, Nan Li, Ming Chen, Hu Li, Jin Zhang*, Xi Wang*. The dynamic landscape of enhancer-derived RNA during mammalian early embryo development. Cell Reports, 2024, 43(4):114077.

2. Hua Yu#, Zhen Sun#, Tianyu Tan#, Hongru Pan#, Jing Zhao, Ling Zhang, Jiayu Chen, Yuqing Zhu, Lang Chen, Yuyan Xu, Shaorong Gao, George Q. Daley, Jin Zhang*. rRNA Biogenesis Regulates Mouse 2C-like State by 3D Structure Reorganization of Peri-Nucleolar Heterochromatin. Nature Communications, 2021, 12:6365.

3. Anhua Lei#, Hua Yu#, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang*. A second generation M1-polarized CAR macrophage with antitumor efficacy. Nature Immunology, 2023, 25:102-116.

4. Zhen Sun#, Hua Yu#, Jing Zhao#, Tianyu Tan, Hongru Pan, Bo Gao, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Cristina Correia, Ming Chen, Qiming Sun, Li Shen, Longfei Wang, Yu Feng, Jianlong Wang, Xiaohua Shen, Hu Li, Hao Wu, George Q. Daley, Jin Zhang*. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell, 2021, 13:490-512.

5. Jing Zhao#, Ke Yao#, Hua Yu#, Ling Zhang, Yuyan Xu, Lang Chen1, Zhen Sun, Yuqing Zhu, Chen Zhang, Yuli Qian, Zhuyan Ji, Min Zhang, Jie Chen, Cristina Correia, Taylor Weiskittel, Dan Zhang, Hu Li, Wei Xie, Zeping Hu*, Jin Zhang* Metabolic remodelling during early mouse embryo development. Nature Metabolism, 2021, 3:1372-1384

6. Lin Yang, Yuqing Zhu#, Hua Yu#, Xiaolong Cheng, Sitong Chen, Yulan Chu, He Huang, Jin Zhang*, Wei Li*. scMAGeCK links genotypes with multiple phenotypes in single-cell CRISPR screens. Genome Biology, 2020, 21:19.

7. Hua Yu#*, Lu Lu#, Bingke Jiao, Chengzhi Liang*. Systematic discovery of novel and valuable plant gene modules by large-scale RNA-seq samples. Bioinformatics, 2019, 35(3):361-364.

主持项目

(1) 国家自然科学基金青年项目，32100632，rRNA生物合成调控小鼠ES/2C-like细胞群体稳态，2022-2024，30万，在研，主持

(2) 浙江省自然科学基金探索项目，LQ21C120002，核仁应激调控小鼠胚胎干细胞命运决定，2021-2023，10万，已结题，主持

(3) 中国博士后基金面上资助项目，2018M642441，网络流智能算法在药物-疾病关联基因通路预测中的应用，2018/11-2021/04，5万元，已结题，主持