PI课题组

韩仁文

2024-11-04

个人简介

2004年,兰州大学,生命科学生物学学士;

2009年,兰州大学生物化学与分子生物学,理学博士;

2009/07—2011/06香港理工大学深圳研究院,博士后

2011/072013/08,香港理工大学深圳研究院,副研究员;

2013/9—至今,生物医学创新研究院副研究员硕士生导师。

研究方向

主要致力于焦虑、抑郁等精神疾病的发病机制及防治策略的研究。以第一作者或通讯作者在Nature CommunicationsNeuropharmacologyMolecular barin等神经生物学和药理学领域SCI杂志上发表论文10篇。



代表性论文

1. Han Ren-wen *, Zhang Zi-yi, Jiao Chen, Hu Ze-yu, Pan Bing-xing *. Synergism between two BLA-to-BNST pathways for appropriate expression of anxiety-like behaviors in male mice. Nature Communications, 2024, 15:3455.

2. Han Ren-wen *, Liu Zhi-peng#, Lin Hong-ru, Tian Ao-wen, Xiao Yun-fei, Wei Jie, Deng Ke-yu, Pan Bing-xing *, Xin Hong-bo *. Role of Lateral Amygdala calstabin2 in Regulation of Fear Memory. Molecular Brain, 2020, 13(1):35.

3. Han Ren-wen *, Tian Ao-wen, Lin Hong-ru, Chang Min, Wei Jie, Deng Ke-yu, Xin Hong-bo *. Nociceptin impairs acquisition of novel object recognition memory in perirhinal cortex. Neurobiology of Learning and Memory. 2019, 162: 9-14.

4. Han Ren-wen, Xu Hong-jiao, Zhang Rui-san, Wang Pei, Chang Min, Peng Ya-li, Deng Ke-yu, Wang Rui*. Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiology of Learning and Memory. 2014, 107: 32–6.

5. Han Ren-wen, Xu Hong-jiao, Zhang Rui-san, Wang Rui*. The role of apelin-13 in novel object recognition memory. Peptides. 2014, 62: 155–8.

6. Han Ren-wen, Zhang Rui-san#, Xu Hong-jiao, Chang Min, Peng Ya-li, Wang Rui*. Neuropeptide S enhances memory and mitigates memory impairment induced by MK801, scopolamine or Aβ1-42 in mice novel object recognition task. Neuropharmacology. 2013, 70C: 261-7.

7. Han Ren-wen; Zhang Rui-san, Chang Min, Peng Ya-li, Wang Pei, Hu Sheng-quan, Choi Chung-lit, Yin Ming, Wang Rui*, Han Yi-fan*. Reversal of scopolamine-induced spatial and recognition memory deficits in mice by novel multifunctional dimers bis-cognitins. Brain Research. 2012, 1470: 59-68.

8. Han Ren-wen, Yin Xin-qiang, Chang Min, Peng Ya-li, Li Wei, Wang Rui*. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment induced by N-methyl-D-aspartate receptor antagonist in mice. Neuroscience Letters. 2009, 455(1): 74-7.

9. Han Ren-wen, Chang Min#, Peng Ya-li, Qiao Lian-yong, Yin Xin-qiang, Li Wei, Wang Rui*. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009, 30(7): 1313-7.

10. Peng Ya-li, Han Ren-wen#(共同第一作者), Chang Min, Zhang Lei, Zhang Rui-san, Li Wei, Han Yi-fan*, Wang Rui*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides. 2010, 31(12): 2259-63.



主持项目

  1. 国家自然科学基金地区项目,82160270,内质网Ca2+通道调节蛋白calstabin2在杏仁核调控慢性应激诱发焦虑障碍中的作用及机制研究,2022.01-2025.12, 35万元,在研,主持

  2. 国家自然科学基金青年项目,81703495,内质网Ca2+通道调节蛋白FKBP12.6在条件性恐惧记忆中的作用及机制研究,2018.01-2020.12,20.1万元,已结题,主持

  3. 国家自然科学基金地区项目,81460546,孤啡肽在嗅周皮层对物体识别记忆的调节作用及其机制研究,2015.01-2018.12,47万元,已结题,主持