陈廷涛

陈廷涛

研究方向：益生菌、工程菌等活菌制剂开发

教育经历

2002.9~2006.7：山东农业大学，蚕学，农学学士

2006.9~2009.7：西南大学，动物学，理学硕士

2010.9~2013.7：南昌大学，食品科学与工程，工学博士

2011.12~2012.12：美国宾夕法尼亚大学卵巢癌研究中心，留学访问

工作履历

2013.7~2020.12：南昌大学 副研究员

2021.1~至今：南昌大学 研究员

个人荣誉

² 2017年入选江西省杰出青年人才

² 2019年入选江西省省主要学科学术和技术带头人；南昌大学“215人才工程”赣江特聘教授

² 2020年入选江西省双千计划

² 2021年获得中国产学研合作创新奖；中国发明创业奖创新奖；生物医学高价值专利优秀奖

² 2022年获得第三届江西省高校教师教学创新大赛省级特等奖；第二届江西省高校教师教学创新大赛省级二等奖；第二届江西医学科技奖；第二季度“Wiley中国开放科学高贡献作者奖”；第四季度“Wiley威立中国开放科学高贡献作者”

² 2023年获得第三届全国高校教师教学创新大赛国家三等奖；新加坡国际发明展览会金奖/年度最佳商业化奖；第一季度“Wiley中国开放科学高贡献作者奖”

主要业绩

一、主要科研成果

主持国家自然科学基金3项，省自然科学基金12项，横向课题31项，总经费逾2800万。先后获得江西省双千计划（科技创新高端人才项目）、杰出青年、优势科技创新团队、新世纪百千万人才、主要学科学术和技术带头人等省级人才称号。在国内外权威刊物发表学术论文167篇，授权专利30余件。其中，以第一/通讯作者发表SCI论文118篇， IF22>5论文60篇、中科院TOP期刊41篇，工作被Nature、New England Journal of Medicine、Lancet等多家权威期刊正面评述或引用，被《中国肿瘤营养治疗指南2020》引用收录。担任Canadian Journal of Infectious Diseases & Medical Microbiology主编，Frontiers in Immunology副主编，及其他十余家国内外期刊编委、专刊主编。获得产学研合作创新奖、发明创业奖-创新奖、全国高校教师教学创新大赛等国家/省级奖励5项。指导本科生获包括互联网+银/铜奖在内的国家级奖项12项，省级奖项2项。

与青岛东海药业、美华生物、中科嘉亿、江西善行、善恩康、杭州远大、上海医药、博雅生物等公司研发部门合作，共同致力于益生菌的基础研究与产业转化；近5年共给合作企业带来新增销售额10.25亿元，新增利润逾1.48亿元。

1、主持科研课题（部分）

[1] 陈廷涛. 功能性益生菌新产品的开发及作用效果研究, 横向课题, 500万, 2023/01-2032/12.

[2] 陈廷涛. 新型益生菌功能性食品的开发, 横向课题, 500万, 2022/03-2026/12.

[3] 陈廷涛. 新一代功能性益生菌对宿主健康的改善作用及其机制研究, 横向课题, 100万, 2021/05-2024/12.

[4] 陈廷涛. GLP-1工程益生菌的构建及其对糖尿病治疗的微生物生态学和分子生物学机制研究, 国家自然科学基金, 42.50万元, 2021/01-2024/12, 82060638.

[5] 陈廷涛. 呼吸道合胞病毒全人源化单克隆抗体制备及其机理研究, 国家自然科学基金, 45.60万元, 2016/01-2019/12, 31560264.

[6] 陈廷涛. 益生菌发酵药渣及其苷类代谢产物对脾虚小鼠的调理机制研究, 国家自然科学基金, 21.60万元, 2016/01-2018/12, 81503364.

[7] 陈廷涛. 江西省双千计划-科技创新高端人才项目, 200万元, 2019/01-2023/12.

[8] 陈廷涛. pBpp蛋白工程菌株的构建及其对糖尿病治疗效果的评价和作用机制研究, 江西省省主要学科学术和技术带头人培养计划, 50万元, 2019/01-2021/12, 20194BCJ22032.

[9] 陈廷涛. 益生菌组合对鼻咽癌患者放化疗后黏膜炎的缓解作用及其机制研究, 江西省科技厅重点研发计划, 22万元, 2018/01-2020/12, 20181BBG70028.

[10] 陈廷涛. 表达GLP-1工程益生菌的构建及其在防治肥胖中的应用, 江西省省级优势科技创新团队, 30 万元, 2018/01-2020/12, 20181BCB24003.

[11] 陈廷涛. 江西省杰出青年人才项目, 15万元, 2017/01-2019/12, 20171BCB23028.

2、发表代表性论文

Tingtao Chen#*, Chaofei Xia, Hong Hu, Huan Wang, Buzhen Tan, Puyuan Tian, Xiaoxiao Zhao, Le Wang, Yiwen Han, Ke-Yu Deng, Hong Wei *, and Hong-Bo Xin*. Dysbiosis of the rat vagina is efficiently rescued by vaginal microbiota transplantation or probiotic combination. International Journal of Antimicrobial Agents, 2021, 57.3: 106277. (SCI 2区, IF22= 10.8)

Tingtao Chen#, Jing Yuan, Xu Feng, Wei Hua, Benhua Zeng, Huan Tang, Hong Wei*. Effects of enrofloxacin on the human intestinal microbiota in vitro. International Journal of Antimicrobial Agents. 37: 567-571, 2011. (SCI 2区, IF22= 10.8)

Dingfa Lianga#, Fei Wu, Dexi Zhou, Buzhen Tan*, Tingtao Chen*. Commercial Probiotic Products in Public Health: Current Status and Potential Limitations, Critical Reviews in Food Science and Nutrition, 2023, 1-22 (SCI 1区, IF22= 10.2, Top期刊).

Xinyue Hu, Xuan Xu, Xiangdi Zeng, Rui Jin, Shengnan Wang, Huifu Jiang, Yuwen Tang, Guanxiang Chen, Jing Wei, Tingtao Chen*, and Qi Chen*. Gut microbiota dysbiosis promotes the development of epithelial ovarian cancer via regulating Hedgehog signaling pathway, Gut Microbes, 2023 (接收，SCI 1区, IF22= 12.2, Top期刊)

Yao Kong# and Zhaoxia Liu#*, Qin Xiao, Fei Wu, Lijuan Hu, Xiaorong Deng, Tingtao Chen*. Protective effects of engineered Lactobacillus crispatus on intrauterine adhesions in mice via delivering CXCL12. Frontiers in Immunology, 2022. (接收, SCI 2区, IF22= 7.3, Top期刊)

Cihua Zheng# & Tingtao Chen#*, Jiachen Lu, Kehong Wei, Huakai Tian, Weidong Liu, Tian Xu, Xinyu Wang, Shuai Wang, Rong Yang, Yulu Yang, Zhaoxia Liu, Hong Wei* and Xiaorong Deng*. Adjuvant Treatment and Molecular Mechanism of Probiotic Compounds in Patients with Gastric Cancer after Gastrectomy. Food & Function, 2021, 12.14: 6294-6308. (SCI 2区, IF22= 6.1)

Xin Fang#, Xin Wang, Shaoguo Yang, Fanjing Meng, Xiaolei Wang, Hua Wei, Tingtao Chen*. Evaluation of the microbial diversity in amyotrophic lateral sclerosis using high-throughput sequencing. Frontiers in Microbiology. 2016;7. (SCI 2区, IF22= 5.2, Top期刊)（国际上率先证实了肌肉萎缩症患者“脑-肠”的存在，该学术观点被Nature、Gut等国际多家权威期刊正面引用）

Dongwen Ma#, Yidan Chen, Tingtao Chen*. Vaginal microbiota transplantation for the treatment of bacterial vaginosis: a conceptual analysis. FEMS Microbiology Letters. 2019, 366.4. (SCI 4区, IF22= 2.1) 【全球率先系统提出“阴道菌群移植”概念，该观点随后被New England Journal of Medicine（2020）正面引用，且不到一年时间被以色列科学家通过临床试验证实了其可靠性（Nature medicine, 2019））】

Chunling Jiang#, Huan Wang, Chaofei Xia, Qing Dong, En Chen, Yang Qiu, Yong Su, Honghui Xie, Lei Zeng, Jie Kuang, Fan Ao, Xiaochang Gong, Jingao Li*, Tingtao Chen*. A randomised, double-blind, placebo-controlled trial of probiotics to reduce severity of oral mucositis induced by chemoradiotherapy for patients with nasopharyngeal carcinoma. Cancer, 2019, 125.7: 1081-1090. (SCI 1区, IF22= 6.2, Top期刊)（Lancet Oncology《柳叶刀•肿瘤》杂志针对文章做了专题评论；被“热心肠日报”誉为“是国产益生菌在2018年度发表的、仅有的3篇被国际同行评议的RCT研究论文中的2篇”）

Yun Wang#, Wen-jie Chen, Yi-yang Han, Xuan Xu, Ai-xia Yang, Jing Wei, Dao-jun Hong, Xin Fang*, Tingtao Chen*. Neuroprotective effect of engineered Clostridium butyricum-pMTL007-GLP-1 on Parkinson’s disease mice models via promoting mitophagy. Bioengineering & Translational Medicine, 2023. (接收, SCI 2区, IF22= 7.4, Top期刊)

Linxi Ma#, Huaijun Tu *, Tingtao Chen*. Postbiotics in Human Health: A Narrative Review, Nutrients, 2023, 15.2: 291. (SCI 2区, IF22= 5.9, Top期刊).

Ping Lib, Xia He, Enxu Feng, Jing Wei, Huaijun Tua*, Tingtao Chen*. Lactobacillus acidophilus JYLA-126 Ameliorates Obesity-Associated Metabolic Disorders by Positively Regulating AMPK Signaling Pathway through the Gut-Liver Axis, Probiotics and Antimicrobial Proteins, 2023 (接收, SCI 2区, IF22= 4.9)

Xuanqi Zhao#, Heng Wu#, Ruizhe Zhu#, Gaishuang Shang, Jing Wei, Haitao Shang, Puyuan Tian, Tingtao Chen* and Hong Wei*. Combination of thalidomide and Clostridium butyricum relieves chemotherapy-induced nausea and vomiting via gut microbiota and vagus nerve activity modulation, Frontiers in Immunology, 2023. (接收, SCI 2区, IF22= 7.3, Top期刊)

Heng Yang, Wanqi Lan, Wu Liu, Tingtao Chen*, Yanhua Tang*. Dapagliflozin promotes angiogenesis in hindlimb ischemia mice by inducing M2 macrophage polarization, Frontiers in Pharmacology, 2023 (接收, SCI 2区, IF22= 5.6, Top期刊)

Xinlu Zhan, Qi Zuo, Genhua Huang, Yufan Wang, Zhanghua Qi, Sihong Zhu, Yanying Zhong, Yifei Xiong, Tingtao Chen*, Buzhen Tan*. Tripterygium glycosides sensitizes cisplatin chemotherapeutic potency by modulating gut microbiota in epithelial ovarian cancer, Frontiers in Cellular and Infection Microbiology, 2023. (接收, SCI 2区, IF22=5.7)

Kaige Zhang#, Hui Liu#, Peng Liu#, Qi Feng, Lihong Gan, Ling Yao, Gen Huang, Ziling Fang*, Tingtao Chen* and Nian Fang*. Positive Efficacy of Lactiplantibacillus plantarum MH-301 as A Postoperative Adjunct to Endoscopic Sclerotherapy for Internal Hemorrhoids: A Randomized, Double-blind, Placebo-controlled Trial, 2023. (接收, SCI 1区, IF22= 6.1, Top期刊)

Tangchang Xu#, Xia He#, Tingtao Chen*. Editorial: The Role of Probiotics, Postbiotics, and Microbial Metabolites in Preventing and Treating Chronic Diseases, Frontiers in Cellular and Infection Microbiology, 2023. (接收, SCI 2区, IF22=5.7).

Hong Hu#, Jie Luo#, Ying Liu, Hongyu Li, Rui Jin, Shengjie Li, Jing Wei, Hong Wei* and Tingtao Chen*. Improvement effect of a next-generation probiotic L. plantarum-pMG36e-GLP-1 on type 2 diabetes mellitus via gut-pancreas-liver axis，Food & Function, 2023 (接收，SCI 1区, IF22= 6.1, Top期刊).

Jian-zhao Zhang, Fang-yuan Zhu, En-xu Feng, Fei Wu, Xin Fang, Huai-jun Tu, Jin Wei, Ai-lan Wan*, Tingtao Chen*. Adjunct therapy with probiotics for depressive episodes of bipolar disorder type Ⅰ: a randomized placebo-controlled trial，Journal of Functional Foods, 2023，(SCI 2区, IF22= 5.6, Top期刊)

Xiumiao Zhao#, Zhaoxia Liu*, Tingtao Chen*. Potential role of vaginal microbiota in ovarian cancer carcinogenesis, progression and treatment. Pharmaceutics, 2023 (接收，SCI 2区, IF22= 5.4)

Fei Wu#, Yao Kong#, Wenjie Chen, Dingfa Liang, Qin Xiao, Lijuan Hu, Xiao Tan, Jing Wei, Yujuan Liu, Xiaorong Deng, Zhaoxia Liu* and Tingtao Chen*. Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice. BMC Microbiology, 2023. (接收, SCI 3区, IF22= 4.2)

Ruizhe Zhu#, Yilin Fang, Hongyu Li, Ying Liu, Jing Wei, Shuwei Zhang, Liwei Wang, Rui Fan, Lingfang Wang, Shengjie Li*, Tingtao Chen*. Psychobiotic Lactobacillus plantarum JYLP-326 relieves anxiety, depression, and insomnia symptoms in test anxious college students via modulating the gut microbiota and its metabolism. Frontiers in Immunology, 2023 (SCI 2区, IF22= 7.3, Top期刊)

Qing Liu#, Teng Ma#, Cuijiao Feng#, Yalin Li, Hao Jin, Xuan Shi, Lai-Yu Kwok, Yan Shi*, Tingtao Chen*, Heping Zhang*. Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota, Food Science and Human Wellness, 2023 (接收，SCI 1区, IF22= 7, Top期刊).

Feng Huang#, Shengjie Li#, Wenjie Chen, Yiyang Han, Yue Yao, Liang Yang, Qiang Li, Qun Xiao, Jing Wei, Zhaoxia Liu, Tingtao Chen*, Xiaorong Deng* Postoperative probiotics administration attenuates gastrointestinal complications and gut microbiota dysbiosis caused by chemotherapy in colorectal cancer patients, Nutrients, 2023, 15.2: 356. (SCI 2区, IF22= 5.9, Top期刊).

Heng Wu#, Jing Wei#, Xiumiao Zhao, Ying Liu, Zhihang Chen, Kehong Wei, Jiachen Lu, Wenjie Chen, Meixiu Jiang, Shengjie Li*, and Tingtao Chen*. Neuroprotective effects of an engineered E. coli Nissle on Parkinson's disease in mice by delivering GLP-1 and modulating gut microbiota. Bioengineering & Translational Medicine, 2022. (接收, SCI 1区, IF22= 7.4, Top期刊)

Xin-liang Wang#, Wen-jie Chen, Rui Jin, Xuan Xu, Jing Wei, Hong Huang, Yan-hua Tang, Chang-wei Zou*, Tingtao Chen*. Engineered probiotics Clostridium butyricum-pMTL007-GLP-1 improves blood pressure via producing GLP-1 and modulating gut microbiota in spontaneous hypertension rat models, Microbial Biotechnology, 2022 (SCI 2区, IF22= 5.7)

De-xi Zhou#, Xiao-he Wang, Xuan Xu, Wen-jie Chen, Jing Wei, Tingtao Chen*, Hong Wei*. Anti-tumor effects of engineered VNP20009-Abvec-Igκ-mPD-1 strain in melanoma mice via combining the oncolytic therapy and immunotherapy, Pharmaceutics, 2022, 14.12: 2789 (SCI 2区, IF22= 5.4)

Meng-yun Yue#, Jing Wei, Wen-jie Chen, Dao-jun Hong, Tingtao Chen*, Xin Fang*. Neurotrophic role of the next-generation probiotic strain L. lactis MG1363-pMG36e-GLP-1 on Parkinson’s disease via inhib-iting ferroptosis, Nutrients, 2022, 14.22: 4886. (SCI 2区, IF22= 5.9, Top期刊)

Qingyao Shang#, Yuan Gao, Huaijun Tu* and Tingtao Chen*. Editorial: The Role of Dietary Interventions in The Regulation of Host-Microbe Interactions: Volume II, Frontiers in Cellular and Infection Microbiology, 2022, 1730. (SCI 2区, IF22= 5.7).

Wenjie Cao#, Cihua Zheng#, Xuan Xu, Rui Jin, Feng Huang, Meng Shi, Zhipeng He, Yufeng Luo, Lulin Liu, Zhaoxia Liu, Jing Wei, Xiaorong Deng* and Tingtao Chen*. Clostridium butyricum Potentially Improves Inflammation and Immunity through Alteration of the Microbiota and Metabolism of Gastric Cancer Patients after Gastrectomy, Frontiers in Immunology, 2022, 13. (SCI 2区, IF22= 7.3, Top期刊)

Qifa Huang#, Xin Wei, Wenyu Li, Yanbing Ma, Guanxiang Chen, Lu Zhao, Ying Jiang, Siqi Xie and Qi Chen* and Tingtao Chen*. Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating hedgehog Signalling Pathway, Cancers, 2022, 14.21: 5178 (SCI 2区, IF22= 5.2)

Runqiu Chen#, Huaijun Tu* and Tingtao Chen*. Potential Application of Living Microorganisms in the Detoxi-fication of Heavy Metals, Foods, 2022, 11.13: 1905. (SCI 2区, IF22= 5.2)

Hui Liu#, Kaige Zhang, Peng Liu, Xuan Xu, Yuyang Zhou, Lihong Gan, Ling Yao, Bin Li, Tingtao Chen* and Nian Fang*. Improvement Effect of Bifidobacterium animalis subsp. lactis MH-02 in Patients Receiving Resection of Colorectal Polyps: A Randomized, Double-Blind, Placebo-Controlled Trial. Frontiers in Immunology, 2022, 13. (SCI 2区, IF22=7.3, Top期刊)

Fangyuan Zhu#, Huaijun Tu* and Tingtao Chen*. The Microbiota-Gut-Brain Axis in Depression: The Potential Pathophysiological Mechanisms and Microbiota Combined Antidepression Effect. Nutrients, 2022, 14.10: 2081. (SCI 2区, IF22= 5.9, Top期刊)

Changwei Zou#, Ying Chen#, Hongyu Li, Wenyu Li, Jin Wei, Ziyan Li, Xinliang Wang, Tingtao Chen*, Hong Huang*. Engineered bacteria EcN-MT alleviate liver injury in cadmium-exposed mice via its probiotics characteristics and expressing of metallothionein. Frontiers in pharmacology, 2022, 506. (SCI 2区, IF22= 5.6, Top期刊)

Yuqing Zhou, Zhaoxia Liu* and Tingtao Chen*. Gut Microbiota: A Promising Milestone in Enhancing the Efficacy of PD1/PD-L1 Blockade Therapy. Frontiers in Oncology, 2022, 12. (SCI 2区, IF22= 4.7)

Shengjie Li*, Xiumiao Zhao and Tingtao Chen*. The Role of Dietary Interventions in The Regulation of Host-Microbe Interactions. Frontiers in Cellular and Infection Microbiology, 2022, 71. (SCI 2区, IF22= 5.7)

Jiachen Lu#, Jianing Ding#, Zhaoxia Liu*, and Tingtao Chen*. Retrospective analysis of the preparation and application of immunotherapy in cancer treatment (Review). International Journal of Oncology, 2022, 60.2: 1-23. (SCI 2区, IF22= 5.2)

Xin Fang#, Mengyun Yue, Jing Wei, Yun Wang, Daojun Hong, Bo Wang, Xiaoting Zhou*, Tingtao Chen*. Evaluation of the Anti-Aging Effects of a Probiotic Combination Isolated from Centenarians in a SAMP8 Mouse Model. Frontiers in Immunology, 2021 ,5163. (SCI 2区, IF22= 7.3, Top期刊)

Huan Wang#, Jing Wei#, Hong Hu#, Fuyin Le, Heng Wu, Hong Wei*, Jie Luo*, and Tingtao Chen*. Oral administration of bacterial β cell expansion factor A (BefA) alleviates diabetes in mice with type 1 and type 2 diabetes. Oxidative Medicine and Cellular Longevity, 2021, 2022. (SCI 2区, IF21= 7.31)

Xiaoting Zhou#, Jiachen Lu, Kehong Wei, Jing Wei, Puyuan Tian, Mengyun Yue, Yun Wang, Daojun Hong, Fangjun Li, Bo Wang, Tingtao Chen*, Xin Fang*. Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson’s Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota. Oxidative medicine and cellular longevity, 2021. (SCI 2区, IF21= 7.31)

Shengjie Li#, Jing Wei*, Tingtao Chen*. Editorial: Gut Microbiota in the Occurrence, Development and Treatment of Gut-Brain Disorders. Frontiers in Cellular and Infection Microbiology, 2021, 1286. (SCI 2区, IF22= 5.7)

3、成果获奖：

（1）益生菌产业化关键技术的集成与应用, 中国发明创业奖创新奖一等奖, 2021年11月, 陈廷涛（1/6）

（2）产学研合作创新奖, 2021年1月, 陈廷涛（1/1）

（3）动物双歧杆菌在预防结直肠多发息肉术后复发中的应用, 新加坡国际发明展览会金奖/年度最佳商业化奖, 2023年, 陈廷涛（1/1）

（4）第三届全国高校教师教学创新大赛国家级三等奖, 2023年8月, 陈廷涛（3/4）

（5）第三届江西省高校教师教学创新大赛省级特等奖, 2022年5月, 陈廷涛（3/4）

（6）第二届江西省高校教师教学创新大赛省级二等奖, 2022年6月, 陈廷涛（4/4）

（7）多因素阐明男性不育机制及其诊疗体系的开发, 第二届江西医学科技奖, 2022年, 陈廷涛（1/1）

（8）2021生物医学高价值专利优秀奖, 2021年, 陈廷涛（1/1）

（9）第一季度威立Wiley中国开放科学高贡献作者奖, 2023年, 陈廷涛（1/1）

（10）第二、四季度威立Wiley中国开放科学高贡献作者奖, 2022年, 陈廷涛（1/1）