林辉

林辉 博士

南昌大学基础医学院副教授、硕士生导师

赣江青年学者

美国哈佛医学院博士后

教育和工作背景:

2021-至今 南昌大学基础医学院副教授、硕士生导师

2019-2021 美国哈佛医学院博士后

2011-2017 南昌大学临床医学专业 硕-博连读

l 研究兴趣、领域：

主要研究 AMP-激活蛋白激酶(AMPK)和转化生长因子 beta（TGF-beta）超家族信号通路之间的交互作用以及在疾病中的作用。目前主持国家自然科学青年基金1 项，江西省杰出青年自然科学基金 1 项，江西省青年基金 1 项。以第一作者或者通讯作者发表科研 SCI 论文 17 篇。

l 代表性论文：

1. Wu, Jianhui., Ren, Bowen., Wang, Daochao., Hui Lin（*林辉）. Regulatory T cells in skeletal muscle repair and regeneration: recent insights. Cell Death Dis. 2022 Aug 5;13(8):680.

2. Huang, Yifei; Wang, Xinyi; Zhou, Daixuan; Zhou, Wenwen; Dai, Fengyi; Lin, Hui （*林辉）, Macrophages in heterotopic ossification: from mechanisms to therapy., NPJ Regen Med, 2021, 6(1): 70.

3. Wang, Xinyi; Liu, Ting; Huang, Yifei; Dai, Yifeng; Lin, Hui（*林辉）, Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis., Open Biology, 2021, 11(11): 210043.

4. Hou, Yifeng; Cai, Shuang; Yu, Shouyang; Lin, Hui（*林辉）, Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer, Acta Biochimica et Biophysica Sinica, 2021, 53(3): 333-341.

5. Hui Lin（林辉）; Fuli Shi; Shanshan Jiang; Yuanyuan Wang; Junrong Zou; Ying Ying; Deqiang Huang; Lingyu Luo; Xiaohua Yan; Zhijun Luo, Metformin attenuates trauma-induced heterotopic ossification via inhibition of Bone

Morphogenetic Protein signalling., JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24(24): 14491-14501.

6. Lin, Hui（林辉）; Zhou, Wenfang; Huang, Yonghong; Ren, Min; Xu, Fangyun; Wang, Hongmei, Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice., Acta Biochimica et Biophysica Sinica, 2020, 52(4): 421-429.

7. Yifei, Huang; Xinyi, Wang; Hui, Lin（*林辉）, The hypoxic microenvironment: a driving force for heterotopic ossification progression., Cell Communication and Signaling, 2020, 18(1): 20.

8. Lin, Hui（林辉）; Ying, Ying; Wang, Yuan-Yuan; Wang, Gang; Jiang, Shan-Shan; Huang, Deqinag; Luo, Lingyu; Chen, Ye-Guang; Gerstenfeld, Louis C.; Luo, Zhijun, AMPK downregulates ALK2 via increasing the interaction between

Smurfl and Smad6, leading to inhibition of osteogenic differentiation, Biochimica et Biophysica Acta-Molecular Cell Research, 2017, 1864(12): 2369-2377.

9. Lin, Hu（i 林辉）; Li, Nianshuang; He, Huan; Ying, Ying; Sunkara, Shashank; Luo, Lingyu; Lv, Nonghua; Huang, Deqiang; Luo, Zhijun, AMPK Inhibits the Stimulatory Effects of TGF-beta on Smad2/3 Activity, Cell Migration, and Epithelial-to-Mesenchymal Transition, MOLECULAR PHARMACOLOGY, 2015, 88(6):1062-1071.